Brian Hiatt
May 03, 2004 AT 04:00 AM EDT

After ditching her Queen of Nice persona along with her talk show, Rosie O’Donnell is ready to show her soft side again. In her first major acting role since quitting the talk show, she’ll play a mentally handicapped woman in ”Riding the Bus With My Sister,” a movie set to air on CBS, according to the Hollywood Reporter. The movie will be based on a book of the same title that O’Donnell excerpted in her now-defunct Rosie magazine. ”This book touched my soul,” O’Donnell wrote in a blurb for the book’s cover.

In the book, author Rachel Simon tells of spending time with her mentally disabled sister, who spends her time riding city buses. ”It’s kind of like a female ‘Rain Man,”’ executive producer Larry Sanitsky told the Hollywood Reporter. ”[It] says a lot about sisterly relationships and what it’s like? to have a developmentally disabled sibling.” O’Donnell will also be an executive producer on the project.

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