Amy Ryan
October 30, 2008 AT 09:52 PM EDT

Estelle Reiner was a remarkable woman, more than just the mom of actor/director Rob Reiner and wife for nearly 65 years of comedy legend Carl Reiner. Estelle, who died Saturday from natural causes at age 94, was also a painter, a jazz singer (who didn’t begin her recording career until age 65), and an anti-war activist who designed the famous Vietnam-era poster that read, “War is not healthy for children and other living things.” But of course, she was most famous as an actress, one who had bit parts in films directed by her husband or her son, particularly Rob’s When Harry Met Sally (1989), in which she uttered the one punchline at the end of Meg Ryan’s fake-orgasm-at-Katz’s-Delicatessen scene that earned her screen immortality. So watch the clip below and hoist a pastrami sandwich and a bottle of Dr. Brown’s Cel-Ray soda to toast Estelle Reiner’s memory.

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