Wendy Mitchell
March 02, 2010 AT 11:52 PM EST

Variety reports that Joseph Gordon-Levitt will replace James McAvoy in the upcoming comedy formerly titled I’m With Cancer. Seth Rogen also stars in the production for Summit/Mandate. Summit told Variety that McAvoy left the project, set to shoot next week, “due to unrelated circumstances beyond his control.” The cast also features Anna Kendrick, Bryce Dallas Howard, Anjelica Huston, and Philip Baker Hall. Jonathan Levine will direct.

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