Tanner Stransky
September 16, 2011 AT 04:00 AM EDT

When NBC debuted its ambitious Michael Crichton-penned medical drama ER on Sept. 19, 1994, five doctors and one nurse were at the helm of Chicago’s County General Hospital. Although little-known at the time, the actors playing them — Noah Wyle, Sherry Stringfield, Anthony Edwards, Julianna Margulies, George Clooney, and Eriq La Salle — would go on to huge critical acclaim, amassing 23 Emmy nominations and 17 Golden Globe noms in the roles. (And we’re not even counting how many lives they saved!) Here, EW takes a look at what the original inhabitants of County General are up to today.

Julianna Margulies
Nurse Carol Hathaway
Television drama is where it’s at for Margulies: The star was nominated for an Emmy each of the six seasons she was on ER (winning once), and received a second nod for her current role as a betrayed political spouse-turned-lawyer on CBS’ critically lauded The Good Wife.

Eriq La Salle
Dr. Peter Benton
After a smattering of acting and directing gigs post-ER, La Salle has settled into the guest-star life on shows such as 24 and Covert Affairs. He’s next set to appear this fall in several episodes (while possibly directing one) of CBS’ medical drama A Gifted Man.

Sherry Stringfield
Dr. Susan Lewis
Made-for-TV movies are Stringfield’s bread and butter these days, as she recently starred in Lifetime’s Who Is Clark Rockefeller? (alongside fellow Must See TV alum Eric McCormack) and Hallmark’s The Shunning.

Anthony Edwards
Dr. Mark Greene
Edwards keeps a low profile by choice, but he recently wrapped the Jack Kerouac biopic Big Sur alongside Josh Lucas, Kate Bosworth, and Stana Katic and last year starred in Rob Reiner’s Flipped.

Noah Wyle
Dr. John Carter
Since signing out of County General in 2005, Wyle has dabbled in movies (including the controversial W.). But his biggest success came this summer with his starring role as the leader of a group battling alien forces on TNT’s Steven Spielberg-produced sci-fi series Falling Skies.

George Clooney
Dr. Doug Ross
Jeez, whatever happened to this guy? Kidding! The heartthrob of ER went on to become…the heartthrob of the entire world. As if that’s not enough, he’s got artistic cred to boot. Clooney has picked up five Oscar noms (and one win) since playing Dr. Ross. This fall he’s appearing in the political drama The Ides of March (Oct. 7), which he also directed, and The Descendants (Nov. 23).

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