Marc Snetiker
April 27, 2012 AT 07:45 PM EDT

Spin-off or sequel? Judd Apatow’s new comedy This Is 40, which picks up with the lives of married couple Pete (Paul Rudd) and Debbie (Leslie Mann) a few years after the events of Knocked Up, is both.

Of course, saying “a few years after the events of Knocked Up” sounds like a sci-fi catastrophe occurred in Katherine Heigl’s uterus, but the new entry from the Apatow team is a lighthearted spin-off that looks at middle-age married life through the lens of a quarrelling, albeit still in love, couple. Melissa McCarthy and Jason Segel pop up in the trailer, and you can expect appearances from Megan Fox, Lena Dunham, Chris O’Dowd, John Lithgow and Annie Mumolo when the film comes out on December 21. Check out the first trailer below:

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