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August 08, 2012 at 06:22 PM EDT

Academy Award nominated actor Bob Hoskins is retiring after being diagnosed with Parkinson’s disease. In a statement from his agent, the 69-year-old actor “is now looking forward to his retirement with his family, and would greatly appreciate that his privacy be respected at this time,” according to the BBC. “He wishes to thank all the great and brilliant people he has worked with over the years, and all of his fans who have supported him during a wonderful career,” read the statement.

During a screen career that spanned four decades, Hoskins played a colorful variety of tough guys from both sides of the law. He was nominated for an Oscar in Neil Jordan’s Mona Lisa (1986), and he starred as the streetwise gumshoe in Who Framed Roger Rabbit (1988). His most recent role was as one of the dwarves in this summer’s Snow White and the Huntsman.

Read more:

Bob Hoskins’ best on-screen roles

Bob Hoskins: Working Class Hero

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