Natalie Abrams
September 03, 2014 AT 12:00 PM EDT

Sheldon’s cross-country train trip will take him on quite an adventure when The Big Bang Theory returns.

CBS released the first photos from the upcoming season premiere, which feature Sheldon having a grand old time in various places, including Chicago, before seemingly falling victim to thievery in Arizona.

How bad does his trip get? Well, he ends up in his underwear.

Fortunately, Amy and Leonard make the trek to Arizona to pick him up.

Elsewhere, Penny interviews for a job at Bernadette’s pharmaceutical company, headed up by guest-star Stephen Root. (Have you seen his stapler?)

Of course, it’s not long before Sheldon is back in his spot in the safety of Pasadena.

The Big Bang Theory returns Sept. 22 at 8 p.m. on CBS.

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