Devan Coggan
September 01, 2015 AT 06:18 PM EDT

In the new trailer for Miss You Already, Toni Collette and Drew Barrymore star as Milly and Jess, two best friends who’ve been inseparable since childhood. But their lifelong friendship is thrown into disarray when they’re both hit with life-changing news: Milly has cancer, and Jess is pregnant.    

Directed by Catherine Hardwicke, who helmed Twilight and Thirteen, Miss You Already also stars Dominic Cooper and Paddy Considine as the two women’s husbands, and Jacqueline Bisset plays Milly’s mother.

Miss You Already will make its world premiere at the Toronto International Film Festival before hitting U.S. theaters on Nov. 6. 

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