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Brad Pitt and Jennifer Aniston: Kevin Mazur/WireImage.com; Angelina Jolie: Lester Cohen/WireImage.com

9. BRAD - JEN + ANGIE = BRANGELINA

Brad Pitt and Angelina Jolie already share the unique mutual handicap of being the world's most beautiful movie stars. So when the duo — who both had a knack for on-set romances — teamed up in 2004 for Mr. & Mrs. Smith, the gossip industry raised its alert level to red. By March 2005, Jennifer Aniston had filed for divorce from Pitt, and less than a year later — after months of playing coy — Jolie announced she was bearing Pitt's love child.

CAREER IMPACT: MINOR ''Brangelina'' became a tabloid phenom, but the new couple wisely shifted the focus to their charitable endeavors and ever-growing family (current count at press time: four). Aniston, meanwhile, emerged with copious public goodwill. All three parties continue to look very, very pretty.