A Cry in the Dark (1988)
As an Aussie who maybe killed her child, Streep went brunet, adopted an accent, and launched a catchphrase: ''A dingo ate mah bay-bay!''
Death Becomes Her (1992)
A youth serum turns Streep's plastic-surgery-abusing character from a frumpy actress into a vamp with serious neck problems.
Angels in America (2003)
She played four different characters in the HBO adaptation of Tony Kushner's play, including an elderly male rabbi.
The Devil Wears Prada (2006)
An icy Cruella De Vil wig and even icier voice helped Streep become the ultimate boss from hell, Miranda Priestly.
Julie & Julia (2009)
Just as Julia Child made duck à l'orange look easy, Streep's uncanny embodiment of the chef's look and singsong delivery seems effortless.