LITTLE WOMAN WHO RUNS WITH THE WOLVES

She's the Simpson people say they relate to the most. She's a second grader who loves the saxophone, her Malibu Stacy doll, and quantum mechanics. She's a pint-size sister whose bookshelf boasts Little Women, The Baby-Sitters Club, and A Brief History of Time. And starting this month, she'll headline a comic book of her very own. The press release promises something unique in comic-book annals: ''a story in the tradition of Nancy Drew, Little Lulu, and Hillary Clinton!'' ''This is a very daring experiment,'' says Simpsons creator Matt Groening. ''I hesitate to use the word in conjunction with comics, but this one is literary. Most comic books have been aimed at underachievers. This one's for overachievers.'' Lisa Comics, written and designed by women, follows Lisa on a journey into a world of ridiculous adults. She's confronted by angry women in the land of Cross Words. She meets Back Words men (Bob & Otto) who speak in palindromes, and she encounters a little dinosaur called The Thesaurus (''a genuine, authentic, veritable, walking, talking emporium of words, a living, breathing compendium of expressions '') who can't seem to shut up. ''It's about little events, exchanges, and wordplay rather than action,'' says designer Mili Smythe. ''And, of course, Lisa is the only one who makes sense.'' The entire Lisa team is hoping that this brainy rather than brawny story will invite more little girls into the world of comics. ''I can't believe it's taken comics this long for there to be a strong-willed little heroine,'' says Groening. ''Betty and Veronica are very nice but '' But they'll never compare to a girl who toots a mean sax.