47. JULIANNE MOORE
Safe (1995)

If Safe had been released a few years later, she'd have earned a nod. Relatively unknown in 1995, the now-four-times-nominated Moore wheezed, coughed, and fainted as Carol White, a wispy California housewife suffering from ''environmental illness.'' Dropping 10 pounds for the role made Moore physically sick; judging from the eerie blankness she mastered, her loss was certainly the performance's gain.