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Knocked Up (2007)
Will Heigl's role as an aspiring entertainment reporter who gets pregnant after a one-night stand with a shlubby dude (Seth Rogen) turn her into a big-screen star? Let's just say that headlining an R-rated Judd Apatow comedy (The 40 Year-Old Virgin) didn't work out too badly for The Office's Steve Carell.
