2. ''You're going to die, Charlie.''

No one saw this one coming — unless, of course, you can see the future like Desmond. In ''Flashes Before Your Eyes,'' we learned that after turning the failsafe key in The Hatch, Desmond went back in time for a brief spell, then returned to the present with visions of the future — specifically, of Charlie's inevitable death. It was a bold and weird development, giving the Scot superpowers, but Lost managed to pull it off in a truly poignant fashion that captured the imagination. Even better, it set Charlie up for some of his finest moments in the series.