The Queen of Nice turned nasty during her one-year stint on the buzzy morning gabfest at least when she was dealing with co-host Elisabeth Hasselbeck. The clashes between the pair most common during political discussions were the stuff of legend, all leading up to their final, cable-news-style, split-screen smackdown on May 25, 2007. O'Donnell never returned to the show after that day, later saying in a video on her website: ''When I saw the split screen, that's when I knew it was over.''
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Simon Cowell isn't the first star to walk away from a megahit. (Neither was Paula!) Look back at these seemingly unimaginable departures from ''Grey's,'' ''The View,'' ''ER,'' and more