George & Weezy Jefferson, The Jeffersons
Played by: Sherman Hemsley and Isabel Sanford
Age gap: 21 years
Crunching the numbers: Sanford's age was movin' on up when she was cast at 58 years old to play the wife of Hemsley, who could have easily been her son. Emmy voters apparently favored age over beauty, nominating Hemsley only once in comparison to Sanford's seven nods (she took home a statuette in 1981).