Satirizing everyone from Ben Affleck to the Pope, Trey Parker and Matt Stone’s brainchild has become the most mature program about the most immature children on the planet. Not only has South Park made astute observations about fame, money, religion, politics, and, of course, poo, but the animated series has managed to stay relevant, regardless of how many years it has been on air. As Eric Cartman would say: Respect its authoritah! —Kate Ward