Zombieland (2009)
Screenwriters Rhett Reese and Paul Wernick originally wanted Patrick Swayze to appear in their irreverent horror comedy. But after Swayze became ill, the pair managed to snag the eccentric, reclusive Ghostbusters star instead and by donning zombie makeup and musing about 2004's Garfield, Murray turned his cameo into an instant classic.
James Van Der Beek plays himself on ''Don't Trust the B--- in Apartment 23,'' joining a parade of celebs in the roles they were born to play, from Neil Patrick Harris in ''Harold and Kumar'' to Mike Tyson in ''The Hangover''