Tara Thornton, True Blood (2008-present)
Outrageous misfortunes: Raised by an alcoholic, neglectful, abusive mother; crashed her car into a tree while driving drunk; fell under the thrall of an evil maenad; mourned the accidental death of her murderous boyfriend; attempted suicide; held hostage by a vampire; nearly killed by a different vampire; trapped in an occult shop that was nearly destroyed; shot in the back of the head; turned into a vampire, the thing she hates most; tried to burn herself to death in a tanning bed; captured and imprisoned by the Vampire Authority.
The bottom line: If all that happened to us, we might run away to be a cage fighter in New Orleans too.